In contrast, tau-seeding activities in non-AD samples were significantly lower than that in AD samples at ∼57 h (p = 0.0087 for 0N3R; p = 0.0019 for 1N3R; p = 0.0037 for 2N3R; p = 0.0344 for 0N4R; p = 0.0001 for 2N4R; Figure 4). This evidence concerns the gene MAPT and Alzheimer disease.