MAPT and Alzheimer disease: Tau-ASA, represented by the percentage of tau ThT fluorescence at the endpoint of brain tissues after RT-QuIC assay, indicated significantly higher levels of misfolded tau seeds from tauopathies brains that included 16 cases of AD, 8 cases of CBD, 6 cases of PiD, and 7 cases of PSP (n = 37 in total) than those from non-tauopathy controls (n = 14) (Figure 2B, P < 0.0001 or 0.0004).