Tau aggregates are present not only in AD brains, but also in multiple neurodegenerative diseases known as “tauopathies” (Arai et al., 2001; Lee et al., 2001), including Pick’s disease (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). This evidence concerns the gene MAPT and neurodegenerative disease.