Different tau strains can be faithfully amplified in vitro from tau isolated from different tauopathy brains and that the amplified tau variants retain their strain-dependent pathogenic characteristics (Xu et al., 2021), our full-length tau isoform-based RT-QuIC assays therefore presumably reflect more faithfully the pathological molecular species of AD brains because full-length tau isoforms are the native forms of tau proteins in human brains (Goedert et al., 1992) and hence offer potentially more accurate diagnosis of AD and other tauopathies for future translational applications. Here, MAPT is linked to tauopathy.