Expression of STING, TBK1, and IRF3 phosphorylation, as well as the nuclear translocation of IRF3, were significantly elevated in the hippocampus and white matter of rats with CCH, and this elevation was paraleled by upregulated levels of key proinflammatory cytokines and increased neutrophil infiltration. Here, IRF3 is linked to columnar cell hyperplasia of the breast.