Here, we found that STING, p-TBK1, and p-IRF3 were widely expressed in neurons, microglia, and astrocytes in brain tissues after CCH, corroborating previous findings that the STING pathway is activated in microglia and leads to IR-induced neuroinflammation and brain injury (Liao et al., 2020). This evidence concerns the gene IRF3 and columnar cell hyperplasia of the breast.