In a mice model of sepsis-induced cardiomyopathy, the activation of STING/IRF3 leads to inflammatory reactions and further increases the expression of the NLRP3 inflammasome, while STING knockdown suppresses myocardial and serum inflammatory cytokines and alleviates cardiac function (Li et al., 2019). Here, STING1 is linked to cardiomyopathy.