To examine whether STING, TBK1, and IRF3 are needed for the neuroinflammatory responses induced by CCH and whether the inhibitory effect of RES on cerebral inflammatory responses is related to the expression of STING, TBK1, and IRF3, we examined the temporal patterns of STING, TBK1 and IRF3 expression in the hippocampus and white matter of 2VO rat. This evidence concerns the gene IRF3 and columnar cell hyperplasia of the breast.