To further investigate the effect of RES on microglia following CCH, we performed Immunohistochemical staining for the microglial marker Iba-1 in white matter after CCH and showed the morphology of Iba1 positive glia in the white matter of rats at 4 and 8 weeks after sham or 2VO operation (Figure 7A). Here, AIF1 is linked to columnar cell hyperplasia of the breast.