Thus, BACE1-inhibitor intervention might be ideally started before to the accumulation of the Aβ-protein, synaptic loss as well as the onset of potentially irreversible cognitive deficits in order to achieve a positive outcome on cognition (Moussa-Pacha et al., 2019; Hampel et al., 2020). This evidence concerns the gene BACE1 and Cognitive impairment.