INS and Brain atrophy: On the other hand, regarding increased BMI, increased visceral fat deposition might affect brain atrophy and Aβ deposition (Kim H. J. et al., 2015) through several potential mechanisms, including increased insulin resistance (Jack et al., 2013; Luchsinger et al., 2013), lower levels of adipose-derived hormones (Montague et al., 1998), and a larger pattern of proatherogenic gene expression (Yao et al., 2012).