For CL cutoff-based Aβ positivity, decreased BMI (OR = 1.56, 95% CI 1.06–2.29) was associated with a greater risk of Aβ positivity after controlling for age, sex, APOE e4 genotype, years of education, hypertension, diabetes, baseline BMI, and BMI variability (Table 2). The gene discussed is APOE; the disease is diabetes mellitus.