The overrepresentation of the ITGA2 +/+ polymorphism in grade II, but not in higher-grade astrocytomas, could be explained by the hypothesis that this polymorphism could have a lower tendency to evolve to higher grades or due to the lower percentage of secondary glioblastoma cases (5%) (1), hampering the identification of genetic abnormalities. The gene discussed is ITGA2; the disease is astrocytoma (excluding glioblastoma).