IL34 and leukoencephalopathy with calcifications and cysts: In the normal epithelium of paracancerous tissues in RCC and LCC, the expression of the innate immune regulator IL-34 was also higher in LCC than in RCC, which indicated that IL-34 was involved in the nontumor-specific innate immune mechanism, which was dominant in LCC but suppressed in RCC (Figure 6).