PTEN and pachyonychia congenita: More importantly, KCNK15-AS1 suppressed KCNK15 translation through interacting with the 5′UTR of KCNK15, while KCNK15-AS1 also promoted PTEN expression and thus inhibited the Akt pathway, thereby suppressing PC cell proliferation, migration, and invasion (133, 134) (Table 2; Figure 2).