As mentioned before, METTL14 was involved in various cellular processes of PC cells, since METTL14 remarkably promoted PC cell proliferation, migration, and invasion; metastasis; cisplatin resistance; and GEM resistance while it inhibited the apoptosis and autophagy of PC cells (7, 157–159) (Table 3). Here, METTL14 is linked to pachyonychia congenita.