TP53 and pachyonychia congenita: Currently, aberrant genetic mutations (KRAS, p53, CDKN2A, SMAD4), dysregulation of the key signaling pathway (TGF-β, Wnt/β-catenin, Notch, Hippo, YAP), and epigenetic alterations (DNA methylation, RNA methylation, posttranslational modifications) have been reported to participate in PC development (3, 4).