demonstrated that m6A writer METTL3 elevated both the m6A level and RNA stability of LINC00857 to promote LINC00857 expression, and then LINC00857 functioned as a ceRNA to regulate E2F3 expression through sponging miR-150-5p, contributing to the malignant development of PC cells (125) (Table 2; Figure 2). This evidence concerns the gene METTL3 and pachyonychia congenita.