YTHDF2 and pachyonychia congenita: Moreover, FTO reduced the m6A level of PJA2 and increased PJA2 expression via YTHDF2-mdeidated RNA degradation of PJA2, thereby suppressing the Wnt pathway and forming a functional FTO/YTHDF2/PJA2/Wnt axis to inhibit PC malignant progression (8) (Table 4; Figure 2).