FBXL5 and pachyonychia congenita: In a summary, FBXL5 served as a tumor suppressor in PC carcinogenesis through the ALKBH5–FBXL5–IRP2/SNAI1 axis in an m6A-dependent manner (Figure 2), indicating a potential role of FBXL5 in the diagnosis, prognosis, and target therapy of PC.