For example, in comparison with other genes, genes with high SNV frequencies, such as EGFR (n=11 immune cell types), NTRK3 (n=11), ERBB4 (n=9), and KRAS; genes with high CNV rates, such as RIT1 and NTRK1; and genes with high methylation differences between tumor and normal tissues, such as KIT, were correlated with the increased immune cell abundance. The gene discussed is KIT; the disease is neoplasm.