Rb phosphorylation was reduced not only by abemaciclib but also by lenvatinib, although to a lesser extent, in all three HCC cell lines; interestingly, a further downregulation was induced by the combination, resulting in a stronger inhibition of c-myc expression, whose transcriptional modulation by E2F is well-recognized (34). Here, RB1 is linked to hepatocellular carcinoma.