The TM4SF5/CD44 interaction activates the proto-oncogene tyrosine-protein kinase Src (c-Src)/signal transducer and activator of transcription 3 (STAT3)/Twist-related protein 1 (Twist1)/B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) signaling pathway (120), and epithelial-mesenchymal transition (EMT) (111), which makes TM4SF5/CD44 a potential target for tumor-targeted therapy with coexpression of TM4SF5 and CD44. Here, STAT3 is linked to neoplasm.