This elevated CPT1C expression caused by miR-200c-deficiency was further confirmed as the CPT1C protein level was substantially enhanced in miR-200c-KO MCF12A cells containing WTp53 (MCF-12A-Sg1 and -Sg2, Figure 6A), and the CPT1C mRNA expression was higher in the cohort of p53 wild-type breast cancer patients with low expression of miR-200c (Figure 6B), raising the possibility that Mutp53 might activate CPT1C expression through downregulating miR-200c. This evidence concerns the gene TP53 and breast carcinoma.