Since FAO contributes to the generation of cytosolic NADPH, which is important for cancer cells to counteract oxidative stress (33), and a previous study revealed that CPT1A-driven FAO decreases ROS levels to avoid anoikis in colorectal cancer (CRC) cells (34), we hypothesized that Mutp53-CPT1C-enhanced FAO activity is critical for maintaining redox homeostasis in BLBC. The gene discussed is CPT1C; the disease is cancer.