However, silencing CPT1C interfered with lung metastasis of BLBC cells, as the total metastatic burden quantified by luciferase activity was significantly decreased in MDA-MB-231-Luc2-siCPT1C#3 cells, indicating CPT1C might facilitate distal metastasis, which is in line with the clinical observation that CPT1C expression is higher in breast cancer patients with metastatic tumors (P<0.01; Figure 7C). The gene discussed is CPT1C; the disease is breast cancer.