However, the positive role of WTp53 in FAO seems contradictory to the extremely high mutation rate of TP53 and the metabolic preference of FAO in BLBC, as FAO contributes to tumorigenesis (14, 15), metastasis (16–18), cancer stem cell properties (19), chemo-resistance (19) and tumor recurrence (20) in BLBCs. The gene discussed is TP53; the disease is cancer.