CPT1B and nasopharyngeal carcinoma: In another study, PGC-1α, the key transcription coactivator regulating CPT1A and CPT1B, binds to the transcription factor CEBPB to promote CPT1A expression, which enhances FAO activity to maintain the high NADPH/NADP+ ratio, contributing to radiation resistance of nasopharyngeal carcinoma cells (58).