The whole-genome sequences of the breast tumors indicated that the 10 most frequently mutated genes were TP53, PIK3CA, MYC, CCND1, PTEN, ERBB2, the ZNF703/FGFR1 locus on chromosome 8, GATA3, RB1 and MAP3K1[11]. The gene discussed is TP53; the disease is breast neoplasm.