Several clinical trials have been initiated or are ongoing to investigate the role of ncRNAs in personalized cancer medicine, such as miR-31 (ClinicalTrials.gov Identifier: NCT03362684) and lncRNA CCAT1 (ClinicalTrials.gov Identifer: NCT04269746) in CRC, miR-21 in breast cancer (ClinicalTrials.gov Identifier: NCT05151224), and lncRNA HOTAIR in thyroid cancer (ClinicalTrials.gov Identifer: NCT03469544). The gene discussed is HOTAIR; the disease is thyroid cancer.