LINC01273 promotes the stability of miR-600, enhances the inhibitory effect of miR-600 on METTL3 mRNA, leads to the downregulation of METTL3 expression, and promotes HCC cell sorafenib resistance. LINC01273 can be recognized and degraded by METTL3/YTHDF2. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.