However, there are few reports that abnormal m6A regulatory factors of lncRNAs affect the stemness of HCC cells.LncRNA DUXAP8 increases the m6A level through METTL3 and its own stability and activates downstream target genes MAPK1 and MAPK-ERK signaling pathways through the competitive binding of miR-584-5p to promote the process and stem cell characteristics of HCC (61). This evidence concerns the gene METTL3 and hepatocellular carcinoma.