A small subset of lesser discussed sourcenodes involving metabolic co-morbidities and AD ranked as relatively importantby SemNet version 2 include the following: metformin (a drug used to treat type2 or adult-onset diabetes), dexamethasone (a glucocorticoid use to treatinflammation, autoimmune disease, or adrenal insufficiency), carbonic anhydrase(a family of enzymes that catalyze the interconversion between carbon dioxideand water), and nitric oxide synthase 3 (generates NO in blood vessels and isinvolved with regulating vascular function). The gene discussed is NOS3; the disease is Adrenal insufficiency.