The SNc, LC, and dorsal motor nucleus of the vagus all have Cav1.3 L-type Ca2+ oscillations that contribute to mitochondrial oxidant stress, poor calcium buffering capacity, and are neuronal populations particularly vulnerable to degeneration in Parkinson’s disease (Guzman et al., 2009, 2010, 2018; Goldberg et al., 2012; Sanchez-Padilla et al., 2014; Surmeier et al., 2017; Gonzalez-Rodriguez et al., 2020; Zampese and Surmeier, 2020). Here, CACNA1D is linked to Parkinson disease.