In addition, magnetic resonance angiography showed selective amplification of basilar, internal carotid, and middle cerebral artery signals after MCAO via a three-stage EE paradigm designed according to different stages of cerebral ischemia, which was regulated partially by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3 (GSK-3)/β-catenin and the axon guidance molecules (Zhan et al., 2020). The gene discussed is AKT1; the disease is Cerebral ischemia.