Fulminant DNAm- and GE changes in both neurons and glia at 24 hours after initiation of status epilepticus were observed. The vast majority of these changes were specific for either neurons or glia. At several epilepsy-related genes, like Hdac11, Spp1, Gal, Drd1 and Sv2c, significant differential DNAm and differential GE coincided. This evidence concerns the gene DRD1 and epilepsy.