Fulminant DNAm- and GE changes in both neurons and glia at 24 hours after initiation of status epilepticus were observed. The vast majority of these changes were specific for either neurons or glia. At several epilepsy-related genes, like Hdac11, Spp1, Gal, Drd1 and Sv2c, significant differential DNAm and differential GE coincided. The gene discussed is HDAC11; the disease is epilepsy.