In VGLUT2-pH expressing neurons, infection with vector containing shRNA against IP6K1 or IP6K3 accelerates the rate of VGLUT2-pH endocytosis (control, green, τ = 57.87 ± 7.91 s; IP6K1 KD, red stripes, τ = 24.48 ± 3.73 s, **p < 0.01, ANOVA; IP6K3 KD, gray stripes, τ = 27.65 ± 2.68 s, **p < 0.01, ANOVA), similar to the KOs. This evidence concerns the gene IP6K3 and infection.