Nevertheless, after adding clinical and biochemical factors (e.g., BUN, creatinine, TG, HDL-c, LDL-c, Hs-CRP, hemoglobin, cystatin C, and HbA1c) as the control variables, the multivariable models observed that newly diagnosed diabetes status at baseline was associated with a 0.50-fold increase in the risk of cognitive function decline, suggesting that there might be various clinical and biochemical factors related to cognitive function among individuals with different diabetic status. The gene discussed is CRP; the disease is diabetes mellitus.