CST3 and diabetes mellitus: Nevertheless, after adding clinical and biochemical factors (e.g., BUN, creatinine, TG, HDL-c, LDL-c, Hs-CRP, hemoglobin, cystatin C, and HbA1c) as the control variables, the multivariable models observed that newly diagnosed diabetes status at baseline was associated with a 0.50-fold increase in the risk of cognitive function decline, suggesting that there might be various clinical and biochemical factors related to cognitive function among individuals with different diabetic status.