In this study, we retrospectively analyzed the relationship between the clinical parameters (including age, gender, WHO pathological grade, tumor size, tumor site, clinical treatment regimens, and PTE area) or some molecular markers (Ki-67, MGMT, IDH-1, and p53) and the tumor recurrence patterns identified on MRI in patients pathologically diagnosed with HGG. The gene discussed is MKI67; the disease is neoplasm.