Probiotics can inhibit the nuclear factor kB pathway in intestinal epithelial cells, thereby increasing IL-22 expression, which plays an important role in stabilizing the internal environment and tissue repair and affecting cellular value-added, differentiation, apoptosis, and immune effects by regulating the tyrosine protein kinase-1 (JAK1)/signal transduction-activated transcription factor-3 (STAT3) signaling pathway and downregulating TG synthesis-related genes; the expression of fatty acid transporter protein (FATP) was downregulated to inhibit hepatocyte steatosis. This evidence concerns the gene IL22 and steatosis.