FTO and neoplasm: For instance, ALKBH5 regulated Tregs and MDSC accumulation via modulating the expression of Mct4/Slc16a3 [44]; FTO facilitated immune invasion and desensitized tumor cells to T cell cytotoxicity [45]; YTHDF1 was correlated with immune cell infiltration but attenuated DCs' cross-presentation capacity [46, 47].