These studies indicated that NF-κB signaling pathway functions in most of cells in tumor microenvironment, such as tumor-associated macrophages (TAMs), dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, natural killer T (NKT) cells, T cells, and B cells, and regulates the expression of immune checkpoints, such as PD-L1 [4, 6, 7]. This evidence concerns the gene NFKB1 and neoplasm.