In vitro, lncRNA-MALAT1 was able to encourage the growth and migrant ability of thyroid cancer and reduce cell death, which makes it possible for the invasion, metastasis, and further deterioration of thyroid tumors; after silencing lncRNA-MALAT1, the development of thyroid cancer was remarkably inhibited, and the rate of apoptosis was accelerated. The gene discussed is MALAT1; the disease is thyroid tumor.