Teng et al. reported that lncRNA POT1-AS1 directly targets miR-145-5p and activates VEGFR-2 signal pathway by up-regulating the expression of plasminogen activator inhibitor-1 (SERPINE1), thus promoting tumor progression and angiogenesis in GC cells, suggesting that POT1-AS1 seems a new index and potential therapeutic goal [13]. This evidence concerns the gene SERPINE1 and gastric cancer.