During the development of PAH, knockdown of TUFM by ShRNA not only showed a decreased TUFM level but also demonstrated a reduced expression of mitophagy indicator, such as BECN1 and LC3II/I, along with an increased P62 level (Figures 3(a) and 3(b)–3(e)). Here, TUFM is linked to pulmonary arterial hypertension.