Among the MCODE genes screened above, we found that BCL2, CARM1, CASP8, HDAC3, HDAC6, MCL1, NR3C1, BACE1, CASP1, CCR5, and CTSBT2D were expressed in another independent dataset (GSE182923) with T2DM samples. The gene discussed is HDAC6; the disease is type 2 diabetes mellitus.