CTLA4 and hepatocellular carcinoma: Despite such a chronically immunosuppressed environment, ICI therapy has shown great promise in HCC with recent clinical trials showing the benefit of anti-PD1 or anti-CTLA4 treatment alone or in combination with antiangiogenic therapy (CHECKMATE 40, KEYNOTE 240, and KEYNOTE 224) [1, 3, 19, 22–26].