KRT1 and Kindler syndrome: Mutations in the K1 gene give rise to a rare autosomal recessive disorder (<200 reported cases), referred to as Kindler Syndrome (KS), which derives its name from the English physician, Theresa Kindlin, who first reported the disorder in 1954 is one of the epidermolysis bullosa diseases and is associated with poikiloderma, skin blistering, photosensitivity and skin atrophy in infants with symptoms changing during patient aging.