shed some further light on the Treg cells involved in atherosclerosis demonstrating that IL-35 promotes a subset of CCR5+ Treg cells, which are characterized by elevated expression of immunosuppressive genes such as TIGIT, Pdcd1, Ctla4, Adora2a, Lag3, Havcr2, and Il10. This tissue Treg cell population is important for the prevention of the formation of atheroscerotic lesions (97). This evidence concerns the gene IL10 and atherosclerosis.