Surprisingly, m1A also has such potential, as regulators of m1A modification markedly affected glioma prognosis, with NML, TRMT6, TRMT10C, TRMT61B, ALKBH1, ALKBH3, YTHDF1, YTHDF2, and YTHDF3 as risk factors but YTHDC1 as a protective factor (Figure 2). This evidence concerns the gene ALKBH1 and central nervous system cancer.