Notably, PAT2 and PAT5 had lymphocytes with the highest T cell-mediated cytotoxic activity against SW620 cells (p.G12V mutated KRAS CRC cells), which was consistent with the observed mutational regression (p.G12V/p.G13D inprimary→p.G13D in metastatic tumor). This evidence concerns the gene SLC36A2 and colorectal carcinoma.