The authors found recurrent mutations with subclonal changing patterns in different genes, including KRAS, SYNE1, CACNA1H, PCLO, FBXL2, and DNAH11, giving evidence of a potential mechanism of tumor cell immune escape by analyzing HLA-related clonal neoantigens and immune cell components in CRC liver metastases (15). This evidence concerns the gene CACNA1H and colorectal carcinoma.