Phase I and II trials of axicabtagene ciloleucel, anti-CD19 CAR T-cells with CD28 costimulatory domain, have demonstrated anticancer response in refractory NHL when combined with cyclophosphamide and fludarabine chemotherapy, with an ORR of 82% and complete response rate of 54% in more than 100 treated patients (90). Here, CD19 is linked to non-Hodgkin lymphoma.