GNA13, belonging to a subfamily of G protein-coupled receptors of the Gα subunit, promotes tumor growth and angiogenesis by upregulating CXCL1, CXCL2, and CXCL4 via the IKKβ/NF-κB signaling pathway in CRC cells (49). The gene discussed is CXCL1; the disease is colorectal carcinoma.