For example, deletion of miR-146a-5p results in a breakdown of immune tolerance and development of a fatal spontaneous autoimmune disorder, whereas Foxp3 acting together with miR-155-5p blocks key inducers of effector lineage commitment, such as Satb1 and zinc finger E-box binding homeobox (98–100, 328). Here, FOXP3 is linked to autoimmune disease.