Moreover, mice with specific deletion of METTL14 in CD4+ T cells developed spontaneous colitis, characterized by increased inflammatory cell infiltration along with a marked increase of Th1 cytokines (IFN-γ and TNF-α) and Th17 cytokines (IL-17a and IL-17c) in colonic epithelial (91). This evidence concerns the gene METTL14 and colitis.