In our research, we identified 92 metabolic genes related to TP53 mutation, and results of KEGG analysis showed that mutated TP53 principally participated in glycolysis/gluconeogenesis, tryptophan metabolism, glutathione metabolism, glycosphingolipid biosynthesis, and purine metabolism, which may promote tumor progression via meeting increased demands for energy, biomass, and nutrients. Here, TP53 is linked to neoplasm.