A recent comparison of RNA-sequencing datasets identified shared transcriptional changes involving the innate immune response upon infection of HIEs with multiple human enteric viruses, including genes associated with Toll-like receptors, IFN receptors (IFNAR, IFNGR, IFNLR), IFN-stimulated genes, and IFN-associated chemokines (28). The gene discussed is IFNA1; the disease is infection.