Although the role of IL-37 in the animal model and clinical patients with atherosclerosis (93–96), acute coronary syndrome (1, 97), coronary artery calcification (98), coronary heart disease (99), chronic heart failure (100), atrial fibrillation (101), abdominal aortic aneurysm (102), hypertension (103), and other cardiovascular system diseases (91) has been identified, the timeline view of co-citation clusters revealed that the relationships between IL-37 and the cardiovascular system diseases remain the future hotspots. This evidence concerns the gene IL37 and Hypertension.