Su (17) summarized the expression and release of IL-37, IL-37-dependent intracellular and extracellular signaling, genetic variants, pathophysiological effects, IL-37-induced effects on cholesterol homeostasis, regulation of innate and acquired immunity, the role of IL-37 in mesenchymal stem cell, immune cells, autoimmune diseases, and cancer. The gene discussed is IL37; the disease is autoimmune disease.