On the other hand, a growing body of research has been performed to identify the correlation of IL-37 in several disorders such as mycobacterial infection, colitis, SLE, RA, insulin resistance, and psoriasis (12, 37, 38, 87–89) Similarly, cluster #7 (disease pathogenesis) and cluster #1 (disease activity) still focus on the underlying mechanisms. Here, IL37 is linked to systemic lupus erythematosus.