discussed the mechanism underlying the low abundance of tumor-infiltrating CD8+ T cells in EGFR-mutant NSCLC: the exosomes secreted by the EGFR-mutant NSCLC lines PC9 and HCC827 promoted the apoptosis of CD8+ T cells more than the EGFR wild-type cell lines H1299 and SK-MES-1 (100). Here, CD8A is linked to neoplasm.