A more recent study established that the disappearance of follicular helper CD4+ T (TFH)-B-tissue-resident memory CD8+ T (TRM) cooperation mediated by the CXCL13-CXCR5 axis in EGFR-mutant NSCLC may account for poor responses to ICIs (135). This evidence concerns the gene EGFR and non-small cell lung carcinoma.