In pancreatic cancer, collagen stimulated CXC chemokine ligand-5 (CXCL5) production through the DDR1/PKCθ/spleen tyrosine kinase (SYK)/nuclear factor κB (NF-κB) pathway, which induced neutrophil extracellular traps (NETs) to drive tumor metastasis (17). Here, SYK is linked to pancreatic neoplasm.