In addition, quercetin alleviates inflammatory responses by activating SIRT1 and inhibit NF-κB pathway (159), furthermore, it contributes to anti-inflammatory effect by modulating SIRT1 activation via AMPK/SIRT1/Nfr2/TNFα pathway (203), as well as counteracts cholesterol-induced activation of the NF-κB pathway in the pancreas and normalized the expression of pro-inflammatory cytokines by increasing SIRTI expression (214), and reduce inflammation response in obesity mice through AMPKα1/SIRT1 pathway (215). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.