Quercetin, as SIRT1 agonists, promotes mitochondrial biogenesis thereby attenuates mitochondrial diseases (221), prevented cholesterol-induced mitochondrial bioenergetic dysfunction by upregulating the expression of SIRT1 in the Min6 cells (214), and promotes mitochondrial biogenesis in the brain by activating the transcription of SIRT1 (222, 223). Here, SIRT1 is linked to mitochondrial disease.