SIRT1 and inborn mitochondrial metabolism disorder: Quercetin, as SIRT1 agonists, promotes mitochondrial biogenesis thereby attenuates mitochondrial diseases (221), prevented cholesterol-induced mitochondrial bioenergetic dysfunction by upregulating the expression of SIRT1 in the Min6 cells (214), and promotes mitochondrial biogenesis in the brain by activating the transcription of SIRT1 (222, 223).