Quercetin inhibited oxidative stress to ameliorate diabetic encephalopathy via SIRT1/ER stress pathway in db/db mice (210), furthermore, it inhibited oxidative stress damage to regulate mitophagy and ER stress via SIRT1/TMBIM6 (transmembrane BAX inhibitor-1 motif-containing 6) in cardiovascular diseases (211), as well as attenuated collagen-induced oxidative stress in mice arthritis by mediating SIRT1 activation (212). The gene discussed is TMBIM6; the disease is cardiovascular disorder.