(82) found that MSC-Exos contained several mRNAs (such as indoleamine 2,3-dioxygenase, thymosin beta 10 pseudogene 1, etc.)and proteins (such as macrophage inhibitory cytokine 1, galectin-1, heat shock protein 70, etc.)with anti-inflammatory properties, and these anti-inflammatory substances could promote the formation of Tregs in the mouse spinal cord and inhibit the secretion of IL-6, IL-12p70, IL-17AF and IL-22 from PBMCs to cure MS. This evidence concerns the gene IDO2 and myeloid sarcoma.