The results of miRNA microarray showed that the level of miR-548a-3p in serum exosomes of RA patients was significantly reduced, and was negatively correlated with inflammatory indicators such as serum CRP and rheumatoid factor (RF), so miR-548a-3p may serve as a biomarker for predicting disease activity in RA (87). This evidence concerns the gene CRP and rheumatoid arthritis.