This study revealed the molecular mechanisms of nodosin against CRC: 1) Downregulation of TRIB3 and upregulation of OSGIN1 to induce oxidative stress in cells; 2) Elevation of HMOX1 expression to induce apoptosis; 3) Upregulation of CTSL and LC3 expression to trigger autophagy (As shown in Figure 7). Here, TRIB3 is linked to colorectal carcinoma.