Similar changes in TME are also observed in tumor tissues treated with other agents, such as inhibitors of KMT6A (EZH2), KDM1A (LSD1), PRMT5, and BET proteins (Hemmings and Restuccia, 2012; Kikuchi et al., 2015; Garcia and Shaw, 2017; Herzig and Shaw, 2018; Hoxhaj and Manning, 2020). Here, EZH2 is linked to neoplasm.