Moreover, OGT is associated with TETs to control O-GlcNAcylation of histone H2B for activation of gene transcription (Chen et al., 2013; Ito et al., 2014), while OGT is coordinated with EZH2 to modulate H3K27me3 for silence of tumor suppressor genes (Chu et al., 2014). Here, EZH2 is linked to neoplasm.