IDH1 inhibitors suppress the production of 2-HG that is a kind of oncometabolite in IDH1-mutant cells; AGI-5198 prompts demethylation of H3K9me3 and H3K27me3 in IDH1-mutant chondrosarcoma cells; GSK-321 induces DNA hypomethylation in IDH1-mutant AML cells. Here, IDH1 is linked to chondrosarcoma.