DLG4 and Mental deterioration: The presynaptic vesicle protein synaptophysin and postsynaptic protein PSD-95 play crucial roles in synaptic transmission, synaptic maturation, and synaptic plasticity, and if the molecular network between synapses controls the transmission of synaptic signals and synaptic plasticity, then disturbances in synaptic function may lead to long-term neuronal damage and cognitive decline (Lee et al., 2016).