The genomic characteristics of TNBC endow it with a higher propensity to generate neoantigens (Bianchini et al., 2016), thereby inducing a more friendly tumor microenvironment (TME) (Lei et al., 2020), characterized by more tumor-infiltrating T cells and a higher level of PD-L1 expression (Keenan and Tolaney, 2020; Denkert et al., 2018; Loi et al., 2019). Here, CD274 is linked to neoplasm.