High PD-L1 has been detected in tumor cells, including breast cancer, renal cell carcinoma, colorectal cancer, non-small cell lung cancer, etc., (Thompson et al., 2004) and is associated with a worse prognosis than low PD-L1 expression tumors (Ohaegbulam et al., 2015). The gene discussed is CD274; the disease is renal cell carcinoma.