Alveolar epithelial cells/endothelial cells participate in IPF via various ways, including unfolded protein response (UPR), Epithelial-mesenchymal transition (EMT), coagulation cascade, angiogenesis, and the secretion of a variety of signaling factors (such as TGF-β) (Margaritopoulos et al., 2017; Upagupta et al., 2018; Chanda et al., 2019; Hill et al., 2019; Salton et al., 2019; Selman and Pardo, 2020). This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.