SPPL2C and idiopathic pulmonary fibrosis: The mutations of the gene DSP (Mathai et al., 2016; Wang et al., 2018) and DPP9 (associated with cell adhesion) (Fingerlin et al., 2013; Zhou and Wang, 2016), AKAP13 166] and FAM13A (associated with RhoA/ROCK signaling pathway) (Hirano et al., 2017; van Moorsel, 2018), and SPPL2C (associated with intramembrane proteases) (Wu et al., 2016; Lorenzo-Salazar et al., 2019) were reported to be a risk of IPF susceptivity, progression and prognosis.