TGFB1 and pulmonary fibrosis: Because senescent cells that resist apoptosis can continuously produce profibrotic cytokines, which in turn aggravate pulmonary fibrosis, the induction of apoptosis in senescent cells (e.g., dasatinib/quercetin, ABT-263, and NOX4 inhibitors) or selective antagonism of profibrotic senescence-related factors (e.g., IL-6, TGF-β or leukotrienes) may help to alleviate IPF (Merkt et al., 2020).