Among four surfactant, genetic mutations of SFTPA (Wang Y. et al., 2009; Guenther et al., 2019), SFTPC (Venosa et al., 2017) and ABCA3(Zhou et al., 2017; Manali et al., 2019) have been identified in IPF patients. The gene discussed is SFTPA2; the disease is idiopathic pulmonary fibrosis.