By summarizing the components of ROS, the role of oxidative stress in gliomas pathogenesis, the effects of oxidative stress on targets such as Nrf2, NOX2, NOX4, DGAT1, PKM2, PTPN2, PHB, OSMR, and PAX6 are presented in this paper, and some phytochemicals shown to alter glioma cell growth by affecting oxidative stress are discussed. Here, NFE2L2 is linked to glioma.