Autophagy increases H2O2 levels by promoting p53-mediated GSH depletion and inducing Bcl2 interacting protein 3 (BNIP3) upregulation, mitochondrial damage, and AIF translocation from the mitochondria to the nucleus, resulting in glioma cell death (Wang et al., 2020). This evidence concerns the gene BNIP3 and central nervous system cancer.