Celastrol is one of the most important active ingredients of the traditional Chinese medicine Tripterygium wilfordii, which activates the JNK pathway and ROS production and inhibits the activities of mechanistic targets of rapamycin (mTOR) and Akt kinases, significantly increasing apoptosis and autophagy in glioma cells (Liu et al., 2019). Here, MAPK8 is linked to central nervous system cancer.