NOX4 and glioblastoma: Functional annotation analysis of differentially methylated genes in pediatric GBM and adult GBM identified ROS regulation as a vital process in pediatric GBM and ROS-related genes neutrophil cytosolic factor 1 (NCF1) and NOX4 are upregulated and play important roles in chemosensitivity and proliferation (Jha et al., 2014).