To better elucidate the molecular mechanisms underlying PAAD, we performed functional enrichment analysis of the identified HSRGs and found that they were closely correlated with angiogenesis, hypoxia response and the apoptotic process, and the HIF-1 signaling pathway and glycolysis/gluconeogenesis were the most enriched signaling pathways, suggesting that suggest these genes are tightly associated with cancer-related pathways. This evidence concerns the gene HIF1A and cancer.