TNF and COVID-19: The results showed that 99 targets could be aggregated into eight modules, such as Coronavirus disease-COVID-19, Toll-like Receptor Cascades, Toll-like receptor signaling pathway, Rheumatoid arthritis, NF-kappa B signaling pathway, MAPK signaling pathway, TNF signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, which were mainly involved in immune response, inflammatory progression and bacterial and viral expression (Figure 3).