The levels of these cytokines are positively correlated with the severity of the disease [Liu, Y. et al. 2019-novel coronavirus (2019-nCoV) infections trigger an exaggerated cytokine response aggravating lung injury ChinaXiv http://www.chinaxiv.org/abs/202002.00018 (2020)] and lead to lung injury by further aggravating clinical features, and the core mediator of this cytokine storm and its destructive consequences may be TNF (Ablamunits and Lepsy, 2022). The gene discussed is TNF; the disease is COVID-19.